Wii + Flash = WiiFlash

WiiFlash allows you to control your Flash games and applications with the revolutionary Wiimote.

It supports multiple Wiimotes, IR bar and Nunchuk and integrates very well with Papervision3D. All you need is a Bluetooth enabled PC and a Wiimote, of course.
If you want to play with it, go and get the code and subscribe to the WiiFlash mailing list.